Granisetron Hydrochloride

Granisetron Hydrochloride

A powerful and specialised antagonist of 5-HT3 receptors is granisetron. The drug’s antiemetic effects are produced by inhibiting 5-HT3 receptors, which are found both centrally (in the medullary chemoreceptor zone) and peripherally (GI tract). Through the direct reduction of serotonin activity in the area postrema and the chemoreceptor trigger zone, as well as indirect inhibition at the level of the area postrema, this inhibition of 5-HT3 receptors, in turn, limits the visceral afferent stimulation of the vomiting centre.

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