Albendazole

Albendazole

By reducing the worm’s ability to produce energy, albendazole induces degenerative changes in its tegument and intestinal cells, which finally results in the parasite’s immobilization and death. It functions by attaching to the tubulin’s colchicine-sensitive region and preventing tubulin from polymerizing or assembling into microtubules. The glycogen stores of the vulnerable parasites are reduced because cytoplasmic microtubules are essential for increasing glucose uptake in the larval and adult stages. Adenosine triphosphate (ATP), the energy source needed for the helminth’s existence, is produced less frequently as a result of degenerative alterations in the endoplasmic reticulum, the mitochondria of the germinal layer, and the release of lysosomes that follow.

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