Closantel Sodium

Closantel Sodium

Closantel and other salicylanilides have a partially understood molecular mechanism of action. They are all uncouplers of oxidative phosphorylation, which disrupts the process by which ATP, the cellular “fuel,” is produced in the mitochondria of the cell. This appears to happen via inhibiting the activity of the enzymes involved in this process, succinate dehydrogenase and fumarate reductase. The parasite’s motility is affected, along with possibly other processes. It appears that closantel also interferes with the parasite membranes’ ion and liquid transport systems.

Salicylanilides, such as Closantel, have an unclear molecular mechanism of action. They are all uncouplers of oxidative phosphorylation, which disrupts the process by which ATP, the cellular “fuel,” is produced in the mitochondria of the cell. This appears to happen via inhibiting the activity of the enzymes involved in this process, succinate dehydrogenase and fumarate reductase. The parasite’s motility is affected, along with possibly other processes. It appears that closantel also interferes with the parasite membranes’ ion and liquid transport systems.

Salicylaniline antihelminthic Closantel has a distinct anthelmintic spectrum and is clearly harmful to mammals. Many infections of the aforementioned parasitic illnesses in sheep and cattle are treated with closamide sodium.

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